【《We Chinese in AmericaMedia Editor Tang Zhao, September 22, 2022National Institute for Health and Care Research Oxford Health Biomedical Research Centre, The Wolfson Foundation, and MQ Mental Health Research provided funding to conduct a two-year study to understand if COVID-19 is associated with increased risks of neurological and psychiatric sequelae in the weeks and months thereafter. (Photo Credit: medicine.wustl.edu)

The research focused on how long these risks remain, whether they affect children and adults similarly, and whether SARS-CoV-2 variants differ in their risk profiles.

In this analysis of 2-year retrospective cohort studies, the data were extracted from the TriNetX electronic health records network, an international network of de-identified data from health-care records of approximately 89 million patients collected from hospital, primary care, and specialist providers (mostly from the USA, but also from Australia, the UK, Spain, Bulgaria, India, Malaysia, and Taiwan).

A cohort of patients of any age with COVID-19 diagnosed between Jan 20, 2020, and April 13, 2022, was identified and propensity-score matched to a contemporaneous cohort of patients with any other respiratory infection. Matching was done on the basis of demographic factors, risk factors for COVID-19 and severe COVID-19 illness, and vaccination status. Analyses were stratified by age group (age <18 years [children], 18–64 years [adults], and ≥65 years [older adults]) and date of diagnosis. The risks of 14 neurological and psychiatric diagnoses were assessed after SARS-CoV-2 infection and compared these risks with the matched comparator cohort.

The 2-year risk trajectories were represented by time-varying hazard ratios (HR’s) and summarized using the 6-month constant HRs (representing the risks in the earlier phase of follow-up, which have not yet been well characterized in children), the risk horizon for each outcome (ie, the time at which the HR returns to 1), and the time to equal incidence in the two cohorts. Researchers also estimated how many people died after a neurological or psychiatric diagnosis during follow-up in each age group. Finally, researchers compared matched cohorts of patients diagnosed with COVID-19 directly before and after the emergence of the alpha (B.1.1.7), delta (B.1.617.2), and omicron (B.1.1.529) variants.

The analysis of 2-year retrospective cohort studies of individuals diagnosed with COVID-19 showed that the increased incidence of mood and anxiety disorders was transient, with no overall excess of these diagnoses compared with other respiratory infections. In contrast, the increased risk of psychotic disorder, cognitive deficit, dementia, and epilepsy or seizures persisted throughout. The differing trajectories suggest a different pathogenesis for these outcomes. Children have a more benign overall profile of psychiatric risk than do adults and older adults, but their sustained higher risk of some diagnoses is of concern. The fact that neurological and psychiatric outcomes were similar during the delta and omicron waves indicates that the burden on the health-care system might continue even with variants that are less severe in other respects. Our findings are relevant to understanding individual-level and population-level risks of neurological and psychiatric disorders after SARS-CoV-2 infection and can help inform our responses to them.

(Source: National Institute for Health)

This website has a free subscription function, please enter your email address and name (any nickname) in the upper right corner of the page. After subscribing, you can receive timely updates of the website. I hope that new and old readers will actively subscribe, so that we have the opportunity to provide you with better services

Please click: Home (wechineseus.com) for more news and content on this website

Follow The Chinese Media's Twitter account: https://twitter.com/wechineseinus

Follow The Chinese Media's Facebook account: https://www.facebook.com/wechineseinamerica/

 

Translate

简体中文 繁體中文 English Español

訂閱 Subscribe

---- 訂閱須知 INFO ----本网站已经开通免费订阅功能,请在网页右上角输入您的电邮地址及名字(任何昵称)。订阅后您可以及时收到网站的更新通知。希望新老读者踊跃订阅,让我们有机会能够为您提供更好的服务。In the U.S.A., We Chinese in America is the only magazine focusing on Chinese culture, history, and individuals who have contributed significantly to the Chinese community and/or larger community in general as well as information/news important to readers.To keep you informed of the most updated information/news, please subscribe to "We Chinese in America

最新疫情

2022年9月15日    疫情分析

圣地亚哥9月13日 - 9月15日每日新增病例:
9月13日:299
9月14日:479
9月15日:478
3天死亡:4;3天新增住院:21
CDC评估:低风险
圣地亚哥最近7天平均每日新增病例 406,比较前7天平均每日新增 405,上升了 0,5%;
圣地亚哥最近7天累计死亡 9, 比较前7天累计死亡 10,下降了 10.0%
 
   聖地亞哥 加州  全國
 今日新增 473 无数据  40,692
 今日死亡  4 (3天) 无数据  249
 累計確診  918,279 11,171,694  97,430,413
 累計死亡  5,483 95,574  1,078.018